Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain.
CIBER de Enfermedades Respiratorias, Ciberes, Madrid, Spain.
Eur Ann Allergy Clin Immunol. 2020 Mar;52(2):91-93. doi: 10.23822/EurAnnACI.1764-1489.117. Epub 2019 Oct 31.
Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.
克林霉素由于其广谱的抗菌活性而被广泛用于预防和治疗感染。对克林霉素的过敏反应似乎并不常见（不到 1%的药物过敏反应），而且主要表现为迟发型 T 细胞介导的过敏反应。对于诊断，皮肤试验被认为是高度敏感且相对安全的，但也有皮肤和全身反应的报道。激发试验被认为是金标准。然而，它也包括发生严重反应的可能性。我们报告了两例克林霉素迟发性过敏反应的病例，淋巴细胞转化试验阳性证实了这一点，该体外试验因其有用性和安全性而显示出作为一种有前途的诊断方法的潜力。
