迟发型药物超敏反应的体外诊断：机制方面及未满足的需求
In vitro diagnosis of delayed-type drug hypersensitivity: mechanistic aspects and unmet needs.
作者信息
Naisbitt Dean J, Nattrass Ryan G, Ogese Monday O
机构信息
Department of Clinical and Molecular Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Department of Clinical and Molecular Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
出版信息
Immunol Allergy Clin North Am. 2014 Aug;34(3):691-705, x. doi: 10.1016/j.iac.2014.04.009.
Several laboratories use the lymphocyte transformation test for the diagnosis of delayed-type drug hypersensitivity reactions. Recently, the availability of multiple readouts has improved our ability to diagnose reactions. It is important to note that most published studies characterizing the usefulness of diagnostic tests utilize blood samples from well-defined test and control patient groups. The purpose of this article is to briefly summarize the cellular and chemical basis of delayed-type drug hypersensitivity reactions and to review in vitro assays that are available for drug hypersensitivity diagnosis.
几个实验室使用淋巴细胞转化试验来诊断迟发型药物超敏反应。最近，多种读数的可用性提高了我们诊断反应的能力。需要注意的是，大多数描述诊断试验有用性的已发表研究使用的是来自明确界定的试验组和对照组患者的血样。本文的目的是简要总结迟发型药物超敏反应的细胞和化学基础，并综述可用于药物超敏诊断的体外试验。
Zotero 插件