School of Health Professions, University of Alabama at Birmingham, Birmingham, Alabama.
School of Health Professions, University of Alabama at Birmingham, Birmingham, Alabama.
Arch Phys Med Rehabil. 2020 Mar;101(3):524-534. doi: 10.1016/j.apmr.2019.08.488. Epub 2019 Oct 24.
To provide a meta-analysis of articles that have included the timed 25-foot walk (T25FW) in persons with multiple sclerosis (MS), quantify differences in T25FW scores between those with MS and controls without MS, and quantify differences between categories of disability status and clinical disease courses within MS.
The literature search was conducted using 4 databases (Google Scholar, PubMed, Cumulative Index to Nursing and Allied Health, EBSCO Host). We searched reference lists of published articles to identify additional articles.
A systematic literature search identified articles reporting average T25FW performance in seconds between those with MS and controls without MS, between those with MS who had mild and moderate and/or severe disability status, and between relapsing-remitting and progressive clinical courses of MS.
Information was extracted and categorized based on reported data: comparisons of controls without MS and MS, comparisons of mild and moderate and/or severe MS based on study-defined Expanded Disability Status Scale groups, and comparisons of relapsing-remitting and progressive MS clinical courses.
We performed a random effects meta-analysis to quantify differences between groups as estimated by effect sizes (ESs). We expressed the differences in Cohen d as well as the original units of the T25FW (ie, seconds).
There was a large difference in T25FW performance in MS compared with controls without MS (ES=-0.93, mean difference=2.4s, P<.01). Persons with moderate and/or severe disability walked substantially slower compared with mild disability (ES=-1.02, mean difference=5.4s, P<.01), and persons with progressive courses of MS walked substantially slower than relapsing-remitting MS (ES=-1.4, mean difference=13.4s, P<.01).
对纳入多发性硬化症（MS）患者定时 25 英尺步行（T25FW）的文献进行荟萃分析，量化 MS 患者与无 MS 对照者之间 T25FW 评分的差异，并量化 MS 残疾状况和临床病程类别之间的差异。
使用 4 个数据库（Google Scholar、PubMed、护理与联合健康累积索引、EBSCO 主机）进行文献检索。我们搜索了已发表文章的参考文献列表，以确定其他文章。
系统文献检索确定了报告 MS 患者与无 MS 对照者之间 T25FW 平均表现（以秒为单位）、MS 患者中轻度和中度/或重度残疾状态以及复发缓解型和进行性 MS 临床病程之间的文章。
根据报告的数据提取和分类信息：无 MS 和 MS 对照者的比较、根据研究定义的扩展残疾状况量表组对轻度和中度/或重度 MS 的比较、以及复发缓解型和进行性 MS 临床病程的比较。
我们进行了随机效应荟萃分析，以通过效应大小（ES）量化组间差异。我们用 Cohen d 表示差异，并用 T25FW 的原始单位（即秒）表示差异。
MS 患者与无 MS 对照者相比，T25FW 表现差异较大（ES=-0.93，平均差异=2.4s，P<.01）。中度/或重度残疾患者的步行速度明显慢于轻度残疾患者（ES=-1.02，平均差异=5.4s，P<.01），进行性 MS 患者的步行速度明显慢于复发缓解型 MS（ES=-1.4，平均差异=13.4s，P<.01）。
