Ross D E, Ochs A L, Hill M R, Goldberg S C, Pandurangi A K, Winfrey C J
Department of Psychiatry, Medical College of Virginia, Richmond 23298.
Biol Psychiatry. 1988 Oct;24(6):675-88. doi: 10.1016/0006-3223(88)90141-2.
Using high-resolution infrared oculography with digital recording and analysis techniques, we tested several types of eye movements in 19 schizophrenic patients and 11 normal controls. Abnormal slow pursuit eye movements, seen in about half of the patients, were characterized by erratic inaccuracies in position, velocity, and phase. Tracking errors were quantitatively assessed by their root mean square (RMS) error. Position RMS errors fell into two clearly separated groups, with 10 of 19 patients clustering about the normal controls and the remaining 9 having much higher errors than normal. Although several of these poor trackers had an excess of saccades or low pursuit gain, these abnormalities were not primarily responsible for the large erratic tracking errors. Saccades in response to unpredictable target jumps had normal latencies (reaction times) and velocities, but were more hypometric and variable in accuracy than those of controls. These saccadic abnormalities did not correlate with the patients' position RMS errors during slow pursuit.
我们运用带有数字记录和分析技术的高分辨率红外眼动描记法，对19名精神分裂症患者和11名正常对照者的几种眼动类型进行了测试。在大约一半的患者中观察到异常的慢跟踪眼动，其特征是在位置、速度和相位上存在不稳定的不准确情况。跟踪误差通过均方根（RMS）误差进行定量评估。位置RMS误差分为两个明显不同的组，19名患者中有10名聚集在正常对照者周围，其余9名患者的误差比正常情况高得多。尽管这些跟踪不佳的患者中有几名存在过多的扫视或低跟踪增益，但这些异常并非导致大的不稳定跟踪误差的主要原因。对不可预测的目标跳跃做出反应的扫视具有正常的潜伏期（反应时间）和速度，但比对照组的扫视幅度更小且准确性更不稳定。这些扫视异常与患者在慢跟踪期间的位置RMS误差无关。
