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Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine.再生医学中全身给药、靶向特异性、多功能治疗性重组蛋白
Nanomaterials (Basel). 2020 Jan 28;10(2):226. doi: 10.3390/nano10020226.

本文引用的文献

1
Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases.旁分泌-内分泌 FGF 嵌合体作为代谢疾病的有效治疗方法。
EBioMedicine. 2019 Oct;48:462-477. doi: 10.1016/j.ebiom.2019.09.052. Epub 2019 Oct 17.
2
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis.成纤维细胞生长因子 21：代谢稳态的多功能调节剂。
Annu Rev Nutr. 2018 Aug 21;38:173-196. doi: 10.1146/annurev-nutr-071816-064800. Epub 2018 May 4.
3
FGF1 - a new weapon to control type 2 diabetes mellitus.成纤维细胞生长因子1——控制2型糖尿病的新武器。
Nat Rev Endocrinol. 2017 Oct;13(10):599-609. doi: 10.1038/nrendo.2017.78. Epub 2017 Jun 30.
4
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.每周一次给予长效成纤维细胞生长因子 21 类似物可调节肥胖伴高甘油三酯血症患者和非人类灵长类动物的脂质、骨转换标志物、血压和体重。
Diabetes Obes Metab. 2017 Dec;19(12):1762-1772. doi: 10.1111/dom.13023. Epub 2017 Jul 21.
5
FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases.成纤维细胞生长因子21受体激动剂：一类新兴的用于治疗肥胖相关疾病的药物。
Horm Mol Biol Clin Investig. 2017 May 19;30(2):/j/hmbci.2017.30.issue-2/hmbci-2017-0002/hmbci-2017-0002.xml. doi: 10.1515/hmbci-2017-0002.
6
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.向啮齿动物中枢注射成纤维细胞生长因子1可诱导糖尿病高血糖的持续缓解。
Nat Med. 2016 Jul;22(7):800-6. doi: 10.1038/nm.4101. Epub 2016 May 23.
7
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.成纤维细胞生长因子1的内分泌化产生一种新形态且强效的胰岛素增敏剂。
Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16.
8
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes.LY2405319，一种 FGF21 类似物，在 2 型糖尿病肥胖患者中的作用。
Cell Metab. 2013 Sep 3;18(3):333-40. doi: 10.1016/j.cmet.2013.08.005.
9
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.成纤维细胞生长因子：从分子进化到在发育、代谢和疾病中的作用。
J Biochem. 2011 Feb;149(2):121-30. doi: 10.1093/jb/mvq121. Epub 2010 Oct 12.
10
BetaKlotho is required for metabolic activity of fibroblast growth factor 21.β-klotho是成纤维细胞生长因子21代谢活性所必需的。
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7. doi: 10.1073/pnas.0701600104. Epub 2007 Apr 23.

Chronicles of an FGF chimera: The odyssey continues.

作者信息

Flippo Kyle H, Potthoff Matthew J

机构信息

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States; Iowa Neurosciences Institute, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States.

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States; Iowa Neurosciences Institute, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, United States; Department of Veterans Affairs Medical Center, Iowa City, IA 52242, United States.

出版信息

EBioMedicine. 2019 Nov;49:15-16. doi: 10.1016/j.ebiom.2019.10.019. Epub 2019 Oct 28.

DOI:10.1016/j.ebiom.2019.10.019
PMID:31672336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6945278/
Abstract
摘要