Polymer Science and Engineering Division , CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road , Pune 411008 , India.
Rigaku Americas Corporation , 9009 New Trails Drive , The Woodlands , Texas 77381 , United States.
Inorg Chem. 2019 Nov 18;58(22):15017-15020. doi: 10.1021/acs.inorgchem.9b02389. Epub 2019 Nov 1.
The separation of enantiomers is of considerable importance in the preparation of the compounds of biological interests, catalysis, and drug development. Here, we report a novel enantioseparation of styrene epoxides (SOs) resolved in the presence of a pair of enantio-enriched tetrahedral cages. Chiral neutral cages of formula [(PdX*)(COCl)] ([X*] = RRR- or SSS-[PO(N(*CH(CH)Ph)]) are constructed from Pd building units supported by tris(imido)phosphate trianions and chloranilate linkers. These cages exhibit considerable enantioselective separation capabilities toward a series of styrene epoxides via a crystallization inclusion method. A highest enantiomeric excess (ee) value of up to 80% is achieved for the ()-4-fluorostyrene oxide.
对映异构体的分离在生物活性化合物的制备、催化和药物开发中具有重要意义。在这里，我们报道了一种新型的对映选择性分离苯乙烯环氧化物（SOs）的方法，该方法是在一对手性富集的四面笼的存在下实现的。手性中性笼的分子式为[(PdX*)(COCl)]（[X*] = RRR-或 SSS-[PO（（* CH（CH）Ph））]是由 Pd 建筑单元通过三（亚氨基）膦酸盐三阴离子和氯酸盐连接体支撑的。这些笼通过结晶包合方法对一系列苯乙烯环氧化物表现出相当大的对映选择性分离能力。（）-4-氟苯乙烯氧化物的对映体过量（ee）值高达 80%。
