核苷磷酸化酶在 5 位修饰嘧啶核糖核苷中的应用。
Use of nucleoside phosphorylases for the preparation of 5-modified pyrimidine ribonucleosides.
机构信息
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str. 16/10, Moscow 117997, Russia.
出版信息
Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140292. doi: 10.1016/j.bbapap.2019.140292. Epub 2019 Oct 30.
Enzymatic transglycosylation, a transfer of the carbohydrate moiety from one heterocyclic base to another, is catalyzed by nucleoside phosphorylases (NPs) and is being actively developed and applied for the synthesis of biologically important nucleosides. Here, we report an efficient one-step synthesis of 5-substitited pyrimidine ribonucleosides starting from 7-methylguanosine hydroiodide in the presence of nucleoside phosphorylases (NPs).
酶促糖基转移反应是一种将糖基部分从一个杂环碱基转移到另一个杂环碱基的反应，由核苷磷酸化酶（NPs）催化，目前正在积极开发和应用于生物重要核苷的合成。在这里，我们报告了一种在核苷磷酸化酶（NPs）存在下，从 7-甲基鸟苷氢碘酸盐出发，一步高效合成 5-取代嘧啶核糖核苷的方法。
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