Beatch G N, McNeill J H
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Can J Physiol Pharmacol. 1988 Apr;66(4):312-7. doi: 10.1139/y88-053.
The following investigation was designed to assess whether or not streptozotocin diabetes has an influence on the number and severity of ventricular arrhythmias following coronary artery occlusion in the conscious rat. In addition, electrocardiogram and haemodynamic data were compared between streptozotocin groups and control. Diabetes was induced in male Sprague-Dawley rats with streptozotocin (55 mg/kg iv) and left anterior descending coronary artery ligation was performed either 6 or 9 weeks later. Rats were allowed to recover from preparative surgery for 1 week prior to ligation. Streptozotocin diabetes (untreated or insulin controlled) appeared to have little influence on the variables tested. When exposed to equivalent degrees of ischaemia (the rat is a microangiopathy-resistant species), the streptozotocin diabetic rat heart was not appreciably more prone to arrhythmias of any type compared with control.
以下研究旨在评估链脲佐菌素诱导的糖尿病是否会对清醒大鼠冠状动脉闭塞后室性心律失常的数量和严重程度产生影响。此外，还对链脲佐菌素组和对照组的心电图和血流动力学数据进行了比较。用链脲佐菌素（55mg/kg静脉注射）诱导雄性Sprague-Dawley大鼠患糖尿病，6周或9周后进行左冠状动脉前降支结扎。在结扎前，让大鼠从术前手术中恢复1周。链脲佐菌素诱导的糖尿病（未治疗或胰岛素控制）似乎对所测试的变量影响很小。当暴露于同等程度的缺血时（大鼠是一种抗微血管病变的物种），与对照组相比，链脲佐菌素诱导的糖尿病大鼠心脏并未明显更容易发生任何类型的心律失常。
