Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Dermatolog Treat. 2021 Sep;32(6):658-662. doi: 10.1080/09546634.2019.1688230. Epub 2019 Nov 20.
Cutaneous warts, a common skin condition, may resolve spontaneously or become recalcitrant. Diphencyprone has been shown by many studies to have efficacy in treating warts, with varied results.
We aimed to perform a meta-analysis of the cure rate following the use of diphencyprone immunotherapy as a cutaneous wart treatment.
The databases of Medline, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register were searched for prospective and retrospective cohort studies and randomized controlled trials reporting a cure rate for diphencyprone immunotherapy between 1984 and 2018. The Comprehensive Meta-Analysis software (Biostat Inc) was used to perform a meta-analysis of the diphencyprone pool efficacy.
A total of 153 studies were obtained by searching the databases. After screening for eligibility, 14 studies were included (6 prospective studies, 4 retrospective studies, 3 randomized controlled trials, and 1 case report), representing a total of 851 patients. The random-effects pooled efficacy for diphencyprone was 75.5% (95% CI, 64.6%-83.9%; = 87%).
Diphencyprone immunotherapy has a high efficacy to cure warts. This method may be used as an adjunctive modality for the treatment of warts in cases of conventional treatment failure.
皮肤疣是一种常见的皮肤疾病，可能会自行消退，也可能变得顽固难治。许多研究表明，二苯环丙烯酮在治疗疣方面具有疗效，但结果不一。
我们旨在对二苯环丙烯酮免疫疗法治疗皮肤疣的治愈率进行荟萃分析。
检索 Medline、PubMed、Embase、ClinicalTrials.gov 和 Cochrane 对照试验注册中心的数据库，以查找 1984 年至 2018 年期间报告二苯环丙烯酮免疫疗法治愈率的前瞻性和回顾性队列研究和随机对照试验。使用 Comprehensive Meta-Analysis 软件（Biostat Inc）对二苯环丙烯酮的疗效进行荟萃分析。
通过数据库搜索共获得 153 项研究。经过筛选符合条件后，纳入了 14 项研究（6 项前瞻性研究、4 项回顾性研究、3 项随机对照试验和 1 项病例报告），共涉及 851 例患者。二苯环丙烯酮的随机效应 pooled 疗效为 75.5%（95%CI，64.6%-83.9%； = 87%）。
二苯环丙烯酮免疫疗法治疗疣具有很高的疗效。在常规治疗失败的情况下，该方法可作为疣治疗的辅助手段。
