钯介导的未封闭环状烯酮的γ-和 ε-芳基化及烯基化的远程官能团化。
Palladium-Mediated Remote Functionalization in γ- and ε-Arylations and Alkenylations of Unblocked Cyclic Enones.
机构信息
Department of Chemistry , Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road , Bhauri, Bhopal 462066 , MP , India.
出版信息
Org Lett. 2019 Nov 15;21(22):9071-9075. doi: 10.1021/acs.orglett.9b03462. Epub 2019 Nov 4.
We report herein an extensive investigation of simple and regioselective - as well as -γ-arylations of silyl-dienol ethers of unblocked cyclic enones with the utilization of palladium-catalyzed, modified Kuwajima-Urabe conditions. We have also successfully explored a new -ε-arylation of silyl-trienol ethers of π-extended cyclic enones. In addition, we also report, herein, exclusive γ- and ε-alkenylation of silyl-dienol and silyl-trienol ethers of cyclic enones.
我们在此报告了一种广泛的研究，即利用钯催化的改良 Kuwajima-Urabe 条件，对未受阻的环状烯酮的硅基二烯醇醚进行简单、区域选择性的 - 以及 -γ-芳基化反应。我们还成功探索了一种新型的π-扩展环状烯酮的硅基三烯醇醚的 -ε-芳基化反应。此外，我们还报告了环状烯酮的硅基二烯醇和硅基三烯醇醚的γ-和ε-烯丙基化反应。
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