可见光诱导 2-烷基取代苯甲酰胺的分子内 sp³C-H 氧化反应合成功能化异吲哚并苯并呋喃。

Visible-light-induced intramolecular sp C-H oxidation of 2-alkyl-substituted benzamides for the synthesis of functionalized iminoisobenzofurans.

机构信息

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

出版信息

Chem Commun (Camb). 2019 Nov 14;55(92):13908-13911. doi: 10.1039/c9cc07791j.

DOI:10.1039/c9cc07791j

PMID:31681932

Abstract

We have developed a protocol for the synthesis of functionalized iminoisobenzofurans by means of visible-light-induced intramolecular cyclization reactions of 2-alkyl-substituted benzamides. This one step-economical protocol, which involves intramolecular sp3 C-O bond formation, features mild reaction conditions, exclusive chemoselectivity, and high yields.

摘要

我们开发了一种通过 2-烷基取代苯甲酰胺的可见光诱导分子内环化反应合成功能化异吲哚并苯并呋喃的方法。这种一步经济性的方法涉及分子内 sp3 C-O 键的形成，具有温和的反应条件、独特的化学选择性和高收率。