可见光诱导吲哚衍生物的去芳构化氧化和酚衍生物的去芳构化酰胺化反应。
Visible-light-induced dearomative oxamination of indole derivatives and dearomative amidation of phenol derivatives.
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
出版信息
Chem Commun (Camb). 2020 Jul 28;56(60):8436-8439. doi: 10.1039/d0cc03506h.
Herein, we report a protocol for visible-light-induced dearomative oxamination reactions of indole derivatives to afford functionalized spirocyclic products. These step-economical reactions, which involve C-N and C-O bond formation, feature mild conditions, a broad substrate scope, high yields, exclusive diastereoselectivity and step-economy. In addition, a similar protocol could be used to synthesize spirolactams by dearomative amidation of phenol derivatives.
在此，我们报告了一种可见光诱导吲哚衍生物去芳构化氧化胺反应的方案，可得到功能化的螺环产物。这些涉及 C-N 和 C-O 键形成的经济性步骤反应具有条件温和、底物范围广、收率高、非对映选择性好和经济性高的特点。此外，类似的方案也可用于通过酚衍生物的去芳构化酰胺化来合成螺内酰胺。
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