Huang C M, Ruddel M, Elin R J
Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Clin Chem. 1988 Oct;34(10):1957-9.
Nutritional status may be an important factor in the prognosis of morbidity and mortality. We assessed the nutritional status of individuals seropositive for human immunodeficiency virus (HIV) (as confirmed by Western blot) and of patients with AIDS, by determining the concentration in serum of total protein, albumin, prealbumin (transthyretin), and retinol-binding protein. HIV-seropositive individuals showed no significant difference from normal volunteers in values for prealbumin, albumin, and retinol-binding protein. Patients with AIDS showed significantly smaller prealbumin and albumin concentrations than did normal and HIV-positive individuals. There was no significant difference in the concentration of retinol-binding protein among the three groups. The concentration of total serum protein was significantly greater in HIV-positive individuals and in patients with AIDS than in normal individuals. Thus, the nutritional status of patients with AIDS may be a factor for morbidity and mortality.
营养状况可能是影响发病和死亡预后的一个重要因素。我们通过测定血清中总蛋白、白蛋白、前白蛋白（转甲状腺素蛋白）和视黄醇结合蛋白的浓度，评估了人类免疫缺陷病毒（HIV）血清学阳性个体（经免疫印迹法确认）及艾滋病患者的营养状况。HIV血清学阳性个体的前白蛋白、白蛋白和视黄醇结合蛋白值与正常志愿者相比无显著差异。艾滋病患者的前白蛋白和白蛋白浓度明显低于正常个体及HIV阳性个体。三组之间视黄醇结合蛋白浓度无显著差异。HIV阳性个体和艾滋病患者的血清总蛋白浓度显著高于正常个体。因此，艾滋病患者的营养状况可能是影响发病和死亡的一个因素。
