Kenney J A
Howard University College of Medicine, Washington, D.C.
Dermatol Clin. 1988 Jul;6(3):425-34.
Vitiligo is a disease that affects from 1 to 3 per cent of the population. It is characterized by cutaneous white macules that often develop in cosmetically important areas such as the face, the dorsal hands, and the arms. It may be accompanied by ocular abnormalities and a number of associated disorders such as thyroid disease, diabetes, pernicious anemia, and alopecia areata. There is increasing evidence that vitiligo is an autoimmune disease. Although there is as yet no definitive cure, many patients have obtained respectable repigmentation by the use of topical or oral psoralen plus ultraviolet light. When large areas of skin are involved or when the patient is unresponsive to therapy, serious consideration should be given to depigmentation with monobenzone (Benoquin).
白癜风是一种影响1%至3%人口的疾病。其特征是皮肤出现白色斑疹，常出现在面部、手背和手臂等对美观重要的部位。它可能伴有眼部异常以及一些相关疾病，如甲状腺疾病、糖尿病、恶性贫血和斑秃。越来越多的证据表明，白癜风是一种自身免疫性疾病。尽管目前尚无根治方法，但许多患者通过使用外用或口服补骨脂素加紫外线已获得了可观的色素再生。当大面积皮肤受累或患者对治疗无反应时，应认真考虑使用单苯甲醚（白癜净）进行脱色治疗。
