Fröhling P T, Schmicker R, Lindenau K, Vetter K, Kokot F
St.-Josefs-Hospital, Potsdam, GDR.
Contrib Nephrol. 1988;65:123-9. doi: 10.1159/000415757.
KA administration given in addition to a low-protein diet leads to a reduction of PTH secretion followed by diminishing of osteofibrosis. Osteomalacia will also be reduced by a better control of the calcium-phosphate metabolism, an increase of 1,25-(OH)2-D levels, and a lower burden of aluminum. Therapeutic levels of 25-OH-D and calcitonin (caused by simultaneous administration of vitamin D) are probably necessary to achieve this effect. KA are not only the optimum form of substitution in the nutritional treatment of chronic renal failure, but they seem to be very effective in the treatment of renal osteodystrophy.
除低蛋白饮食外给予酮酸（KA）可导致甲状旁腺激素分泌减少，继而骨纤维变性减轻。通过更好地控制钙磷代谢、提高1,25-(OH)₂-D水平以及降低铝负荷，骨软化症也会减轻。可能需要25-OH-D和降钙素的治疗水平（由同时给予维生素D引起）才能达到这种效果。酮酸不仅是慢性肾衰竭营养治疗中替代治疗的最佳形式，而且在肾性骨营养不良的治疗中似乎非常有效。
