Vehbi Koç Eye Hospital and Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Eur J Ophthalmol. 2021 Jan;31(1):184-193. doi: 10.1177/1120672119887095. Epub 2019 Nov 4.
To evaluate choroidal area, stroma/lumen ratio, choriocapillaris vessel density, and choriocapillaris flow area in eyes with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy using enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography.
This retrospective study analyzed enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography scans of 142 eyes of 92 patients with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choroidal area and stroma/lumen ratio were measured by binarization of enhanced depth imaging-optical coherence tomography images. Choriocapillaris vessel density and choriocapillaris flow area were measured at the choriocapillaris level by manual segmentation of optical coherence tomography angiography scans.
The mean stroma/lumen ratio results were 0.361, 0.345, and 0.354 in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy groups, respectively ( > 0.05). The mean whole image choriocapillaris vessel density in uncomplicated pachychoroid group was higher compared with central serous chorioretinopathy and pachychoroid pigment epitheliopathy groups ( < 0.0001). The mean foveal, parafoveal, and perifoveal choriocapillaris vessel densities were lower in central serous chorioretinopathy group than in uncomplicated pachychoroid group ( < 0.0001). The mean choriocapillaris flow area was lower in central serous chorioretinopathy group than in uncomplicated pachychoroid and pachychoroid pigment epitheliopathy groups ( < 0.0001 and = 0.01, respectively).
Our findings suggest that both choroidal vessels and stroma are equally involved in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choriocapillaris segment seems to be more affected in central serous chorioretinopathy compared to uncomplicated pachychoroid and pachychoroid pigment epitheliopathy. However, the reduced optical coherence tomography angiography signal in central serous chorioretinopathy group could be due to shadowing artifact or choriocapillaris hypoperfusion and further studies with higher quality imaging tools are needed.
使用增强深度成像光学相干断层扫描（EDI-OCT）和光相干断层扫描血管造影术（OCTA）评估中心性浆液性脉络膜视网膜病变、单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变患者的脉络膜面积、脉络膜基质/管腔比、脉络膜毛细血管血管密度和脉络膜毛细血管血流面积。
本回顾性研究分析了 92 例 142 只眼的 EDI-OCT 和 OCTA 扫描，这些眼患有中心性浆液性脉络膜视网膜病变、单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变。通过 EDI-OCT 图像的二值化测量脉络膜面积和脉络膜基质/管腔比。通过手动分割 OCTA 扫描测量脉络膜毛细血管水平的脉络膜毛细血管血管密度和脉络膜毛细血管血流面积。
中心性浆液性脉络膜视网膜病变、单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变组的平均基质/管腔比结果分别为 0.361、0.345 和 0.354（>0.05）。单纯性肥厚脉络膜组的全图像脉络膜毛细血管血管密度平均值高于中心性浆液性脉络膜视网膜病变和肥厚性脉络膜色素上皮病变组（<0.0001）。中心性浆液性脉络膜视网膜病变组的黄斑、旁黄斑和视盘周围脉络膜毛细血管血管密度均低于单纯性肥厚脉络膜组（<0.0001）。中心性浆液性脉络膜视网膜病变组的脉络膜毛细血管血流面积低于单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变组（<0.0001 和=0.01）。
我们的发现表明，脉络膜血管和基质在中心性浆液性脉络膜视网膜病变、单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变中均有受累。与单纯性肥厚脉络膜和肥厚性脉络膜色素上皮病变相比，中心性浆液性脉络膜视网膜病变中脉络膜毛细血管段似乎受到更大的影响。然而，中心性浆液性脉络膜视网膜病变组 OCTA 信号降低可能是由于阴影伪影或脉络膜毛细血管灌注不足所致，需要进一步使用更高质量的成像工具进行研究。
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