SOAT1 甲基化与冠心病有关。
SOAT1 methylation is associated with coronary heart disease.
机构信息
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, People's Republic of China.
出版信息
Lipids Health Dis. 2019 Nov 4;18(1):192. doi: 10.1186/s12944-019-1138-9.
BACKGROUND
This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD).
METHODS
DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were measured in peripheral blood leukocytes (PBLs) from 99 patients diagnosed with CHD and 89 control subjects without CHD. A total of 110 CPG sites around promoter regions of them were examined.
RESULTS
Compared with groups without CHD, patients with CHD had lower methylation levels of SOAT1 (P<0.001). When each candidate genes were divided into different target segments, patients with CHD also had lower methylation levels of SOAT1 than patients without (P = 0.005). After adjustment of other confounders, methylation levels of SOAT1 were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150-0.561).
CONCLUSIONS
SOAT1 methylation may be associated with development of CHD. Patients with lower methylation levels in SOAT1 may have increased risks for CHD. Further studies on the specific mechanisms of this relationship are necessary.
背景
本研究旨在探讨胆固醇吸收候选基因的差异 DNA 甲基化是否可以作为冠心病 (CHD) 患者的生物标志物。
方法
测量了 99 名确诊为 CHD 的患者和 89 名无 CHD 的对照组患者外周血白细胞 (PBL) 中候选基因 FLOT1、FLOT2 和 SOAT1 的 DNA 甲基化水平。共检测了它们启动子区域周围的 110 个 CPG 位点。
结果
与无 CHD 组相比，CHD 患者的 SOAT1 甲基化水平较低 (P<0.001)。当将每个候选基因分为不同的目标片段时，CHD 患者的 SOAT1 甲基化水平也低于无 CHD 患者 (P = 0.005)。调整其他混杂因素后，SOAT1 的甲基化水平仍与 CHD 相关 (P = 0.001，OR = 0.290，95%CI：0.150-0.561)。
结论
SOAT1 甲基化可能与 CHD 的发生有关。SOAT1 甲基化水平较低的患者发生 CHD 的风险可能增加。需要进一步研究这种关系的具体机制。
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