Department of Hepatobiliary Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Department of Hepatobiliary Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Oncol Res. 2023 Apr 10;31(2):193-205. doi: 10.32604/or.2023.027112. eCollection 2023.
Sterol o-acyltransferase1 (SOAT1) is an enzyme that regulates lipid metabolism. Nevertheless, the predictive value of SOAT1 regarding immune responses in cancer is not fully understood. Herein, we aimed to expound the predictive value and the potential biological functions of SOAT1 in pan-cancer. Raw data related to SOAT1 expression in 33 different types of cancer were acquired from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. SOAT1 expression was significantly increased in most cancers and showed a distinct correlation with prognosis. This enhanced expression of the SOAT1 gene was confirmed by evaluating SOAT1 protein expression using tissue microarrays. In addition, we found significant positive associations between SOAT1 expression levels and infiltrating immune cells, including T cells, neutrophils, and macrophages. Moreover, the co-expression analysis between SOAT1 and immune genes showed that many immune-related genes were increased with enhanced SOAT1 expression. A gene set enrichment analysis (GSEA) revealed that the expression of SOAT1 correlated with the tumor microenvironment, adaptive immune response, interferon signaling, and cytokine signaling. These findings indicate that SOAT1 is a potential candidate marker for predicting prognosis and a promising target for tumor immunotherapy in cancers.
甾醇 O-酰基转移酶 1（SOAT1）是一种调节脂质代谢的酶。然而，SOAT1 对癌症中免疫反应的预测价值尚未完全阐明。在此，我们旨在阐述 SOAT1 在泛癌中的预测价值和潜在生物学功能。从癌症基因组图谱（TCGA）和基因型组织表达（GTEx）数据库中获取了 33 种不同类型癌症中与 SOAT1 表达相关的原始数据。SOAT1 在大多数癌症中的表达显著增加，并与预后有明显相关性。通过使用组织微阵列评估 SOAT1 蛋白表达，证实了 SOAT1 基因的这种增强表达。此外，我们发现 SOAT1 表达水平与浸润性免疫细胞（包括 T 细胞、中性粒细胞和巨噬细胞）之间存在显著的正相关关系。此外，SOAT1 与免疫基因的共表达分析表明，许多与免疫相关的基因随着 SOAT1 表达的增强而增加。基因集富集分析（GSEA）显示，SOAT1 的表达与肿瘤微环境、适应性免疫反应、干扰素信号和细胞因子信号相关。这些发现表明，SOAT1 是预测预后的潜在候选标志物，也是癌症肿瘤免疫治疗的有前途的靶点。
