Buhl L, Bojsen-Møller M
Department of Neuropathology, Aarhus Kommunehospital, Denmark.
Dan Med Bull. 1988 Jun;35(3):288-90.
The brains from 100 consecutive patients dying in psychiatric departments were subjected to a neuropathological study with a quantitative evaluation of neurofibrillary tangles and senile plaques. Histologically, Alzheimer changes were found in 63.4% of the group with the clinical diagnosis of senile dementia and in 60% of the arteriosclerotic dementia group. In other clinical groups (schizophrenic, manic-depressive, and "other disorders") the percentage of Alzheimer changes was about 30. Thus, Alzheimer changes were not only present in the group of patients with the "correct" psychiatric diagnosis senile dementia, but were also frequent among patients with other psychiatric diseases where no clinical suspicion of Alzheimer's disease had been forecast. Alzheimer's disease may, thus, contribute to or be concealed by other psychiatric diseases and should be considered in all geronto-psychiatric cases.
对100例连续死于精神科的患者的大脑进行了神经病理学研究，并对神经原纤维缠结和老年斑进行了定量评估。组织学上，临床诊断为老年性痴呆的患者组中63.4%发现有阿尔茨海默氏病变，在动脉硬化性痴呆组中为60%。在其他临床组（精神分裂症、躁狂抑郁症和“其他疾病”）中，阿尔茨海默氏病变的百分比约为30%。因此，阿尔茨海默氏病变不仅存在于临床诊断为“正确”的老年性痴呆患者组中，在其他未预测有阿尔茨海默病临床怀疑的精神疾病患者中也很常见。因此，阿尔茨海默病可能促成其他精神疾病或被其掩盖，在所有老年精神科病例中都应予以考虑。
