Eldrup E, Hagen C, Christensen N J, Olgaard K
Department of Internal Medicine and Endocrinology, Copenhagen County University Hospital, Herlev, Denmark.
Dan Med Bull. 1988 Jun;35(3):291-4.
Peripheral venous plasma free and sulfoconjugated catecholamines, dopamine (DA), noradrenaline (NA) and adrenaline (A) were measured in normal men (n = 6-7) during conditions significantly altering adrenal and sympathoadrenal function (influence of corticotropin, furosemide, hypoglycaemia and clonidine), after dopamine receptor blockade with metoclopramide and after meals. Median (range) basal plasma free DA concentration was 0.13 (0-0.72) nmol/l and median (range) basal plasma conjugated DA concentration was 15.16 (6.34-45.03) nmol/l. Meals increased plasma sulfoconjugated DA markedly from a median value of 14.97 nmol/l during fasting experiments to a median value of 33.01 nmol/l (p less than 0.05). Plasma free DA did not change in the meal experiments. No changes in plasma DA were observed after administration of corticotropin, furosemide, clonidine, and metoclopramide or during hypoglycaemia. The results suggest that plasma sulfoconjugated DA is derived at least in part from the gastrointestinal tract and not from the sympathoadrenomedullary system as hitherto proposed.
在正常男性（n = 6 - 7）中，于显著改变肾上腺和交感肾上腺功能的情况下（促肾上腺皮质激素、速尿、低血糖和可乐定的影响）、在用甲氧氯普胺阻断多巴胺受体后以及餐后，测量外周静脉血浆中游离和硫酸结合的儿茶酚胺、多巴胺（DA）、去甲肾上腺素（NA）和肾上腺素（A）。基础血浆游离DA浓度中位数（范围）为0.13（0 - 0.72）nmol/l，基础血浆结合DA浓度中位数（范围）为15.16（6.34 - 45.03）nmol/l。进餐使血浆硫酸结合DA显著增加，从禁食实验期间的中位数14.97 nmol/l增至中位数33.01 nmol/l（p < 0.05）。进餐实验中血浆游离DA未发生变化。给予促肾上腺皮质激素、速尿、可乐定、甲氧氯普胺后或低血糖期间，血浆DA均未出现变化。结果表明，血浆硫酸结合DA至少部分源自胃肠道，而非如迄今所认为的那样源自交感肾上腺髓质系统。
