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复发性多软骨炎伴发肉芽肿性多血管炎 1 例

External dacryocystorhinostomy in patients with granulomatous polyangiitis.

机构信息

Adnexal Service, Moorfields Eye Hospital, London, EC1V 2PD, UK.

出版信息

Eye (Lond). 2020 Aug;34(8):1382-1385. doi: 10.1038/s41433-019-0662-1. Epub 2019 Nov 4.

DOI:10.1038/s41433-019-0662-1
PMID:31685972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7376108/
Abstract

AIM

To review the outcome for primary or revisional external dacryocystorhinostomy in patients with granulomatous polyangiitis.

PATIENTS AND METHODS

Retrospective case-note review to include age at presentation, duration of prior GPA, immunosuppression at time of surgery, nature of first lacrimal surgery, and symptomatic control.

RESULTS

Forty-eight patients (25 female; 52%) presented at an average age of 50.5 years and 7 (15%) had prior lacrimal surgery on one (5/7; 71%) or both sides. The duration of systemic GPA varied, with 40% having disease for up to 3 years prior to lacrimal referral, and 41/48 (85%) being on systemic immunosuppression. Forty-eight patients had 71 affected drainage pathways-having symptoms for an average of 22 months (range <1 month to 7 years). Surgery was undertaken on 70/71 systems-62/70 primary DCRs (20 unilateral; 8 simultaneous bilateral; 13 sequential bilateral). Of nine systems with persistent symptoms after prior surgery, eight underwent revisional surgery (six unilateral; one sequential bilateral). With a follow-up of 2.5 years (range 3 months to 14 years), volume symptoms were cured in all 70 cases. Flow symptoms were controlled in 58/62 (94%) systems after primary DCR, and all eight after revisional surgery. Of four sides with persistent epiphora, one was cured with revisional DCR and three with placement of Jones' canalicular bypass tubes.

CONCLUSION

Mucoid discharge, dacryocystitis and recurrent conjunctivitis were cured in all patients with GPA after either primary and revisional surgery. Continued epiphora was controlled in most patients with additional closed procedures.

摘要

目的

回顾肉芽肿性多血管炎患者行原发性或翻修性外鼻泪囊吻合术的疗效。

患者与方法

回顾性病例分析,包括发病年龄、既往 GPA 病程、手术时的免疫抑制情况、首次泪道手术类型以及症状控制情况。

结果

48 例患者(25 例女性;52%)的平均发病年龄为 50.5 岁,7 例(15%)曾在单侧(5/7;71%)或双侧行过泪道手术。全身 GPA 的病程长短不一,40%的患者在泪道就诊前病程达 3 年以内,48 例患者中有 41 例(85%)接受全身免疫抑制治疗。48 例患者共有 71 条受影响的引流途径,平均症状持续时间为 22 个月(范围<1 个月至 7 年)。71 个系统中有 62 个(70/71)接受了手术治疗,其中 62 个为原发性 DCR(20 例单侧;8 例双侧同期;13 例双侧先后进行)。9 例既往手术有持续性症状的患者中,8 例接受了翻修手术(6 例单侧;1 例双侧先后进行)。随访 2.5 年(3 个月至 14 年)后,70 例患者的溢泪量均得到治愈。原发性 DCR 后 58/62 例(94%)系统的流泪症状得到控制,翻修手术后 8 例均得到控制。4 例溢泪持续的患者中,1 例通过翻修 DCR 治愈,3 例通过放置 Jones 氏泪小管旁路管治愈。

结论

原发性和翻修性手术后,所有 GPA 患者的黏液性分泌物、泪囊炎和复发性结膜炎均得到治愈。大多数患者通过附加的闭合性手术控制了持续的溢泪。

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