动作观察训练可促进多发性硬化症患者的运动改善，并调节功能网络的动态连通性。
Action observation training promotes motor improvement and modulates functional network dynamic connectivity in multiple sclerosis.
机构信息
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy/Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
出版信息
Mult Scler. 2021 Jan;27(1):139-146. doi: 10.1177/1352458519887332. Epub 2019 Nov 5.
We investigated modifications of resting state dynamic functional network connectivity (dFNC) following a 2-week action observation training (AOT) in 46 right-handed healthy controls (HC) and 41 patients with multiple sclerosis (pwMS) and dominant-hand motor impairment, who were randomized to AOT or control (C) training. PwMS had decreased baseline dFNC versus HC. After training, MS groups improved in right upper limb functions, mainly in AOT, and showed dFNC increase (larger in MS-AOT vs MS-C) in sensorimotor and cognitive networks ( range, ⩽0.001-0.01). Both HC groups showed decreased dFNC over time ( range, ⩽0.001-0.01). Clinical improvements following interventions correlated with sensorimotor and cognitive dFNC changes, suggesting their possible role in motor recovery.
我们研究了在 2 周的动作观察训练（AOT）后，静息状态动态功能网络连接（dFNC）的变化，46 名右利手健康对照者（HC）和 41 名多发性硬化症（pwMS）患者，伴有运动功能障碍，他们被随机分配到 AOT 或对照（C）训练。与 HC 相比，pwMS 的基线 dFNC 降低。经过训练，MS 组在右上肢功能方面有所改善，主要是在 AOT 中，并且在感觉运动和认知网络中显示出 dFNC 的增加（MS-AOT 与 MS-C 相比更大）（范围，≤0.001-0.01）。两个 HC 组的 dFNC 随时间呈下降趋势（范围，≤0.001-0.01）。干预后的临床改善与感觉运动和认知 dFNC 的变化相关，表明它们可能在运动恢复中发挥作用。
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