Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China.
Chem Commun (Camb). 2019 Nov 19;55(93):13987-13990. doi: 10.1039/c9cc06567a.
Polyprodrug-based delivery technique is a fast-growing and effective strategy to improve the therapeutic efficacy of small molecule drugs. We herein developed a robust mitoxantrone (MTO)-based polyprodrug nanoplatform for systemic cisplatin prodrug delivery and combination cancer therapy. Our results show that this nanoplatform can concurrently transport MTO and cisplatin to tumor cells and significantly inhibit tumor growth.
基于前药的递药技术是提高小分子药物治疗效果的一种快速发展且有效的策略。本文开发了一种稳健的米托蒽醌（MTO）基前药纳米平台，用于系统递送达卡巴他赛前药并进行联合癌症治疗。我们的研究结果表明，该纳米平台可以同时将 MTO 和顺铂递送到肿瘤细胞中，并显著抑制肿瘤生长。
