离体肺灌注。
Ex-vivo lung perfusion.
机构信息
Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, Canada.
Department of Anaesthesiology, National Heart Centre, Singapore General Hospital, Singapore.
出版信息
Curr Opin Anaesthesiol. 2020 Feb;33(1):50-54. doi: 10.1097/ACO.0000000000000804.
PURPOSE OF REVIEW
Ex-vivo lung perfusion (EVLP) has been developed to expand the donor pool for lung transplantation recipients. The role of EVLP in organ preservation, evaluation and potential reconditioning is reviewed.
RECENT FINDINGS
EVLP has been shown to significantly increase the utilization of donor lungs for transplantation. Evidence suggests that patient outcomes from EVLP lungs are comparable to standard procurement technique. Novel strategies are being developed to treat and recondition injured donor lungs. EVLP may also prove to be a tool for translational research of lung diseases.
SUMMARY
EVLP has been shown to be an effective system to expand donor pool for lung transplantation without detriment to recipients. Future potential ex-vivo developments may further improve patient outcomes as well as increasing availability of donor organs.
目的综述
离体肺灌注（EVLP）的发展旨在扩大肺移植受者的供体池。本文回顾了 EVLP 在器官保存、评估和潜在再处理中的作用。
最近的发现
EVLP 已被证明可显著增加供肺用于移植的比例。有证据表明，EVLP 肺的患者预后与标准采集技术相当。目前正在开发新的策略来治疗和调理受损的供体肺。EVLP 也可能成为肺部疾病转化研究的工具。
总结
EVLP 已被证明是一种有效的方法，可以扩大肺移植的供体池，而不会对受者造成损害。未来的离体发展可能会进一步改善患者的预后，并增加供体器官的可用性。
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