清醒大鼠长期糖皮质激素治疗对交感肾上腺髓质的抑制作用。

Sympathoadrenomedullary inhibition by chronic glucocorticoid treatment in conscious rats.

作者信息

Szemeredi K, Bagdy G, Stull R, Calogero A E, Kopin I J, Goldstein D S

机构信息

Clinical Neurosciences Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.

出版信息

Endocrinology. 1988 Nov;123(5):2585-90. doi: 10.1210/endo-123-5-2585.

DOI:10.1210/endo-123-5-2585

PMID:3168935

Abstract

The effects of chronic glucocorticoid treatment on sympathoadrenomedullary function were assessed in conscious unrestrained Wistar-Kyoto rats. Cortisol (25 mg/kg.day), administered for 7 days using a sc reservoir pump, suppressed activity of the hypothalamo-pituitary-adrenocortical axis, as indicated by markedly decreased levels of corticotropin (ACTH) and corticosterone and decreased adrenal weight. Cortisol also decreased body weight and increased blood pressure to hypertensive levels without affecting plasma sodium or potassium. Basal levels of plasma epinephrine were markedly decreased, indicating suppression of adrenomedullary secretion. Plasma norepinephrine levels also were decreased, but to a smaller extent than epinephrine, and levels of dihydroxyphenylglycol, an intraneuronal metabolite of norepinephrine, were unaffected. Plasma catecholamine responses to nitroprusside-induced hypotension were not altered by cortisol. The results suggest that chronic cortisol treatment suppresses basal hypothalamo-pituitary-adrenocortical and basal adrenomedullary activity in conscious unrestrained rats without impairing reflexive activation of the sympathoadrenomedullary system.

摘要

在清醒无拘束的Wistar-Kyoto大鼠中评估了慢性糖皮质激素治疗对交感肾上腺髓质功能的影响。使用皮下储液器泵给予皮质醇（25mg/kg·天），持续7天，结果显示促肾上腺皮质激素（ACTH）和皮质酮水平显著降低以及肾上腺重量减轻，表明下丘脑-垂体-肾上腺皮质轴的活性受到抑制。皮质醇还使体重减轻，并使血压升高至高血压水平，而不影响血浆钠或钾水平。血浆肾上腺素的基础水平显著降低，表明肾上腺髓质分泌受到抑制。血浆去甲肾上腺素水平也降低，但程度小于肾上腺素，而去甲肾上腺素的神经元内代谢产物二羟苯乙二醇的水平未受影响。皮质醇并未改变血浆儿茶酚胺对硝普钠诱导的低血压的反应。结果表明，慢性皮质醇治疗可抑制清醒无拘束大鼠的基础下丘脑-垂体-肾上腺皮质和基础肾上腺髓质活性，而不损害交感肾上腺髓质系统的反射性激活。