可见光介导的乙烯基芳烃与溴代羧酸盐的氧化偶联反应合成γ-酮酯
Visible-Light-Mediated Oxidative Coupling of Vinylarenes with Bromocarboxylates Leading to γ-Ketoesters.
作者信息
Fang Xing-Xiao, Wang Peng-Fei, Yi Wei, Chen Wei, Lou Sheng-Chun, Liu Gong-Qing
机构信息
School of Pharmacy , Nantong University , 19 Qixiu Road , Nantong 226001 , People's Republic of China.
出版信息
J Org Chem. 2019 Dec 6;84(23):15677-15684. doi: 10.1021/acs.joc.9b02310. Epub 2019 Nov 15.
PMID:31689366
Abstract
A photocatalytic strategy for the synthesis of γ-ketoesters was reported. Using DMSO as both the solvent and terminal oxidant, oxidative coupling of vinylarenes with bromocarboxylates proceeded readily, giving a variety of γ-ketoesters in good isolated yields and with a broad functional-group tolerance.
摘要
报道了一种光催化合成γ-酮酯的策略。以二甲基亚砜作为溶剂和末端氧化剂，乙烯基芳烃与溴代羧酸盐的氧化偶联反应顺利进行，以良好的分离产率得到了多种γ-酮酯，且具有广泛的官能团耐受性。
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