Bästlein C, Burlefinger R, Holzberg E, Voeth C, Garbrecht M, Ottenjann R
Department of Gastroenterology, Munich Hospital, München-Neuperlach, FRG.
Endoscopy. 1988 Sep;20(5):272-5. doi: 10.1055/s-2007-1018192.
We report on a case of nodular lymphoid hyperplasia (NLH) of the small intestine in a patient with common variable immunodeficiency (CVID) syndrome. The CVID syndrome comprises a group of heterogeneous immunological disorders. It is characterised by hypogammaglobulinemia, recurrent sinopulmonary infections, gastrointestinal disorders (including diarrhea, infestation with Giardia lamblia, chronic-atrophic gastritis and nodular lymphoid hyperplasia (NLH), and an increased risk of malignancy. NLH is frequently associated with gastrointestinal lymphomas. It has also been found in the terminal ileum of children and in adult patients with Gardner's syndrome. NLH is found in about 20% of patients with the CVID syndrome. The diagnosis of NLH requires endoscopic and bioptic-histological examinations and the determination of the immunoglobulins.
我们报告了一例患有常见变异型免疫缺陷（CVID）综合征的患者发生小肠结节性淋巴组织增生（NLH）的病例。CVID综合征包括一组异质性免疫疾病。其特征为低丙种球蛋白血症、反复的鼻窦肺部感染、胃肠道疾病（包括腹泻、蓝氏贾第鞭毛虫感染、慢性萎缩性胃炎和结节性淋巴组织增生（NLH））以及恶性肿瘤风险增加。NLH常与胃肠道淋巴瘤相关。它也在儿童的回肠末端以及患有加德纳综合征的成年患者中被发现。在约20%的CVID综合征患者中可发现NLH。NLH的诊断需要内镜检查、活检组织学检查以及免疫球蛋白测定。
