基于振动诱导发射的内标荧光探针用于可视化活细胞中的 PTP1B。
Internal standard fluorogenic probe based on vibration-induced emission for visualizing PTP1B in living cells.
机构信息
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.
出版信息
Chem Commun (Camb). 2019 Dec 17;56(1):58-61. doi: 10.1039/c9cc07680h.
PMID:31690925
Abstract
Herein, as a proof of concept, we developed the first enzymatic VIE fluorogenic probe for protein tyrosine phosphatase 1B (PTP1B). The detection and imaging of PTP1B using VIE in living cells were both realized. Particularly importantly, the designed probe herein provides a guideline and platform for the development of new VIE-based enzymatic probes.
摘要
在此，作为概念验证，我们开发了第一个用于蛋白酪氨酸磷酸酶 1B（PTP1B）的酶促 VIE 荧光探针。实现了活细胞中 VIE 对 PTP1B 的检测和成像。特别重要的是，本文设计的探针为新型 VIE 酶促探针的开发提供了指导和平台。
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