Gold-Catalyzed Highly Diastereoselective Oxy-Propargylamination of Allenamides with -Alkynyl -Boc ,-Acetals.
作者信息
Chen Long, Yu Jianliang, Tang Shengbiao, Shao Ying, Sun Jiangtao
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering , Changzhou University , Changzhou 213164 , China.
出版信息
Org Lett. 2019 Nov 15;21(22):9050-9054. doi: 10.1021/acs.orglett.9b03449. Epub 2019 Nov 6.
A gold-catalyzed oxy-propargylamination of -allenamides has been developed by using -alkynyl -Boc-acetals as the difunctionalization reagents. Typically, this process features the unique proximal addition rather than the common distal nucleophilic addition for gold(I)-activated allenamides. This reaction is atom-economic and provides highly functionalized 1,3-amino alcohol derivatives in good yields with good to excellent diastereoselectivities under mild reaction conditions.
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