Lewis/Brønsted 酸催化 -allenamides 与,-缩醛的催化氨甲基化醚化反应。
Catalytic aminomethylative etherification of -allenamides with ,-acetals enabled by Lewis/Brønsted acid catalysis.
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
出版信息
Org Biomol Chem. 2023 Apr 26;21(16):3340-3344. doi: 10.1039/d3ob00363a.
A novel copper-catalyzed aminomethylative etherification of -allenamides/alkoxyallenes with ,-acetals has been realized under mild reaction conditions, in which every single atom of ,-acetals is incorporated into the newly formed molecules. Furthermore, in the presence of a chiral phosphoric acid, the asymmetric aminomethylative etherification of -allenamides has been accomplished using ,-acetals as bifunctionalization reagents.
一种新型的铜催化的 -烯酰胺/烷氧基丙二烯与 -缩醛的氨甲基化醚化反应在温和的反应条件下实现，其中 -缩醛的每个原子都被整合到新形成的分子中。此外，在手性磷酸存在下， -烯酰胺的不对称氨甲基化醚化反应也可以使用 -缩醛作为双官能化试剂来完成。
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