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结膜肿瘤的管理问题:结膜黑色素瘤和原发性获得性黑色素沉着症

Management Issues in Conjunctival Tumours: Conjunctival Melanoma and Primary Acquired Melanosis.

作者信息

Cohen Victoria M L, O'Day Roderick F

机构信息

Ocular Oncology Service, Moorfields Eye Hospital and St Bartholomew's Hospital, London, UK.

NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital, University College London Institute of Ophthalmology, London, UK.

出版信息

Ophthalmol Ther. 2019 Dec;8(4):501-510. doi: 10.1007/s40123-019-00219-8. Epub 2019 Nov 6.

Abstract

Conjunctival melanoma is a rare malignant condition of the ocular surface. It is potentially lethal, with regional lymph node spread often preceding distant solid-organ metastasis. Due to its rarity and the long latency between treatment and local recurrence or the development of metastases, it is difficult to study. The literature is composed entirely of case series of varying quality, and there is significant variability in the management of this condition. This commentary attempts to distil the evidence base to provide practical management tips for the clinician.

摘要

结膜黑色素瘤是一种罕见的眼表恶性疾病。它具有潜在致死性,区域淋巴结转移通常先于远处实体器官转移。由于其罕见性以及治疗与局部复发或转移发生之间的长时间潜伏期,很难进行研究。文献完全由质量参差不齐的病例系列组成,并且在这种疾病的管理方面存在显著差异。本评论试图提炼证据基础,为临床医生提供实用的管理建议。

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Evaluation of interferon alpha 2b as adjunctive therapy for conjunctival melanoma.干扰素α2b作为结膜黑色素瘤辅助治疗的评估。
Am J Ophthalmol Case Rep. 2019 May 22;15:100467. doi: 10.1016/j.ajoc.2019.100467. eCollection 2019 Sep.
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Treatment of conjunctival melanoma in a Dutch referral centre.荷兰转诊中心的结膜黑色素瘤治疗。
Br J Ophthalmol. 2018 Sep;102(9):1277-1282. doi: 10.1136/bjophthalmol-2017-311082. Epub 2017 Nov 9.
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Acta Ophthalmol. 2017 Jun;95(4):e323-e328. doi: 10.1111/aos.13252. Epub 2016 Oct 24.

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