Ulhaq Zulvikar Syambani
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University of Malang, Batu, Indonesia.
Int J Vet Sci Med. 2019 Oct 18;7(1):31-34. doi: 10.1080/23144599.2019.1675287. eCollection 2019.
Oestradiol (E) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E biosynthesis such as in the brain and myocardial cells have important physiological and pathophysiological roles. E production is catalysed by aromatase (Aro) enzyme. In teleost, two Aro isoforms are distinctly expressed in the ovary and brain. In this study, the role of brain Aro (AroB) in modulating cardiovascular system is investigated. AroB MO-mediated knockdown decreased ventricular functions. Moreover, embryos injected with AroB MO displays a sign in developing heart failure. All the effects caused by AroB MO were partially reversed by exposure to E. Taken together, this study demonstrates the role of AroB in modulating normal cardiovascular function in zebrafish embryos.
雌二醇（E）是一种对心血管系统具有多效性作用的女性生殖激素。局部E生物合成，如在大脑和心肌细胞中的生物合成，具有重要的生理和病理生理作用。E的产生由芳香化酶（Aro）催化。在硬骨鱼中，两种Aro同工型在卵巢和大脑中明显表达。在本研究中，研究了脑Aro（AroB）在调节心血管系统中的作用。AroB吗啉代介导的敲低降低了心室功能。此外，注射AroB吗啉代的胚胎在发育中表现出心力衰竭的迹象。暴露于E可部分逆转AroB吗啉代引起的所有效应。综上所述，本研究证明了AroB在调节斑马鱼胚胎正常心血管功能中的作用。
