Bosshart Patrick D, Kalbermatter David, Bonetti Sara, Fotiadis Dimitrios
Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bern, Switzerland.
Mol Cell Oncol. 2019 Aug 27;6(6):e1646605. doi: 10.1080/23723556.2019.1646605. eCollection 2019.
Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an -lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and -lactate transport.
单羧酸转运蛋白在某些癌症中发挥着重要作用。我们已经报道了一种结合有底物和抑制剂的乳酸转运溶质载体家族16同源物的结构。这些结构显示该转运蛋白处于药理学相关的外向开放构象。结构-功能分析为配体结合和乳酸转运的分子作用机制提供了见解。
