Zachariae H, Larsen P M, Søgaard H
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Dermatologica. 1988;177(3):175-9. doi: 10.1159/000248538.
A case is presented of a 63-year-old female suffering from Buschke-Löwenstein giant condyloma acuminatum of more than 12 years' duration. The lesions had spread from portio and vagina to the bladder and the right ureter resulting in hydronephrosis of the right kidney leading to subsequent surgical procedures including the establishment of an ilealbladder and exstirpation of the right ureter and nephrectomy of the right kidney. Treatment with recombinant interferon alpha-2A 1.8 mU for 5 days a week resulted in steady regression of all tumor masses. After 6 months of treatment the tumors which had covered the whole of vagina and portio and filled out the whole vagina cavity were reduced to 5 small pin-size lesions at the introitus. Initial side effects of flu-like symptoms disappeared spontaneously without discontinuation of treatment.
本文报告一例63岁女性，患Buschke-Löwenstein巨大尖锐湿疣超过12年。病变已从外阴和阴道蔓延至膀胱及右侧输尿管，导致右肾积水，随后进行了包括回肠膀胱术、右侧输尿管切除及右肾切除术在内的外科手术。每周5天使用重组干扰素α-2A 1.8 mU治疗，使所有肿瘤肿块持续消退。治疗6个月后，原本覆盖整个阴道和外阴并填满整个阴道腔的肿瘤缩小为阴道口处5个针头大小的小病灶。类似流感症状的初始副作用未停药即自行消失。
