铁-阿霉素复合物与铜蓝蛋白和脱铁转铁蛋白的相互作用。

Interaction of iron-adriamycin complexes with ceruloplasmin and apotransferrin.

Løvstad R A

Institute of Medical Biochemistry, University of Oslo Sognsvannsveien, Norway.

Int J Biochem. 1988;20(8):783-6. doi: 10.1016/0020-711x(88)90064-x.

Abstract

The present kinetic study suggests that the Fe(II)-adriamycin complex acts as substrate for ceruloplasmin, which oxidizes the complex to the ferric form (Km = 21.7 microM). 2. Apotransferrin readily removes iron from Fe(III)-adriamycin. 3. However, adriamycin, at low concentration, is able to take up some iron from a 20% iron-saturated transferrin solution; a reaction which may take place in vivo.

摘要

目前的动力学研究表明，亚铁（II）-阿霉素复合物作为铜蓝蛋白的底物，铜蓝蛋白将该复合物氧化为铁（III）形式（米氏常数Km = 21.7微摩尔）。2. 脱铁转铁蛋白能轻易地从铁（III）-阿霉素中去除铁。3. 然而，低浓度的阿霉素能够从20%铁饱和的转铁蛋白溶液中摄取一些铁；这种反应可能在体内发生。