Department of Gastroenterology, Groupe Hospitalier Henri Mondor-Albert Chenevier, APHP, Créteil, France.
Faculté de Médecine, Université Paris Est-Créteil (UPEC), Créteil, France.
Leuk Lymphoma. 2020 Mar;61(3):582-587. doi: 10.1080/10428194.2019.1686501. Epub 2019 Nov 6.
Primary colonic mucosa-associated lymphoid tissue (MALT) lymphoma accounts for less than 0.5% of all colon cancers. We report 9 cases of colonic MALT lymphomas (median follow up: 9 [IQR 1-26] years). The disease was multi-focal in 4 patients: the most frequent sites were the cecum in 4 and the rectum in 3 patients. The main endoscopic finding was a polypoid lesion. The treatment modalities were rituximab +/- an alkylating agent ( = 5), an alkylating agent alone ( = 2), surgical resection ( = 1), and endoscopic resection ( = 1). Remission was achieved in 8 cases. Three patients relapsed, and 2 were re-treated. At the end of the study period, 67% of the patients were in remission. All patients were symptom-free. This current series of colonic MALT lymphomas shows the indolent nature of the disease, which may be treated with various modalities.
原发性结内黏膜相关淋巴组织（MALT）淋巴瘤占所有结肠癌的比例不到 0.5%。我们报告了 9 例结内 MALT 淋巴瘤（中位随访时间：9[IQR 1-26]年）。4 例患者的疾病呈多灶性：最常见的部位是 4 例患者的盲肠和 3 例患者的直肠。主要的内镜发现是息肉样病变。治疗方式为利妥昔单抗+/-烷化剂（ = 5）、烷化剂单药（ = 2）、手术切除（ = 1）和内镜下切除（ = 1）。8 例患者获得缓解。3 例患者复发，2 例患者接受再治疗。在研究结束时，67%的患者处于缓解状态。所有患者均无症状。本系列结内 MALT 淋巴瘤显示出疾病的惰性特征，可采用多种方式进行治疗。
