Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Chem Commun (Camb). 2019 Nov 19;55(93):14081-14084. doi: 10.1039/c9cc05691b.
Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC50 value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhanced therapeutic effect, realizing an efficient combination of photodynamic therapy (PDT) and photoactivated chemotherapy.
胆固醇（CHOL）是脂质体不可或缺的组成部分。用 7-去氢胆固醇（7-DHC）替代 CHOL 可以有效地提高包载光敏剂的脂质体在光照下的抗癌活性，使 IC50 值降至 CHOL 对照组的一半左右。单线态氧将 7-DHC 氧化成内过氧化物形式可能是增强治疗效果的原因，实现了光动力疗法（PDT）和光激活化学疗法的有效结合。
