Department of Biology, Biochemistry Unit, University of Pisa, via San Zeno, 51, Pisa 56127, Italy.
Interdepartmental Research Center Nutrafood ''Nutraceuticals and Food for Health'', University of Pisa, Pisa, Italy.
Biochem Soc Trans. 2019 Dec 20;47(6):1931-1940. doi: 10.1042/BST20190749.
The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a preferential precursor for nucleotides synthesis is discussed. The low reliability of ribose in its furanosidic hemiacetal form must have played ab initio against the choice of d-ribose for the generation of d-ribose-5-phosphate, the fundamental precursor of the ribose moiety of nucleotides. The latter, which is instead generated through the 'pentose phosphate pathway' is strictly linked to the affordable and reliable pyranosidic structure of d-glucose.
呈现了核糖呋喃糖支架作为核苷酸合成的关键步骤，然后是核酸合成。基于这样的观点，即选择用于相关代谢目的的分子必须有利于结构定义良好的分子，讨论了核糖作为核苷酸合成优先前体的不适当性。在呋喃糖半缩醛形式中，核糖的可靠性较低，这必然导致 d-核糖而不是 d-核糖-5-磷酸的产生，d-核糖-5-磷酸是核苷酸核糖部分的基本前体。而后者则是通过“戊糖磷酸途径”产生的，与 d-葡萄糖可负担得起且可靠的吡喃糖结构严格相关。
