尼古丁与其受体结合：一个令人困扰的病理药理学问题的新结构。
Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem.
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Neuron. 2019 Nov 6;104(3):431-432. doi: 10.1016/j.neuron.2019.10.029.
PMID:31697916
Abstract
In this issue of Neuron, Gharpure et al. (2019) nearly complete atomic-level descriptions for binding, permeation, and subunit interactions at the two major heteropentameric nicotinic receptors-those governing nicotine's rewarding and aversive effects. Can we finally design highly selective and useful nicotinic drugs?
摘要
在本期《神经元》杂志中，Gharpure 等人（2019）几乎完整地描述了两个主要的异戊二烯型烟碱型乙酰胆碱受体（分别控制尼古丁的奖赏和厌恶效应）在结合、通透和亚基相互作用方面的原子水平细节。我们是否终于可以设计出高选择性和有用的烟碱类药物了？
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