Department of Urology, Radboud University Medical Center, HB Nijmegen, the Netherlands.
Department of Pediatric Urology, University Medical Center Utrecht, Utrecht, the Netherlands.
Urology. 2020 Feb;136:272-277. doi: 10.1016/j.urology.2019.10.011. Epub 2019 Nov 4.
To assess urological function, sexual function, and quality of life in patients with exstrophy or epispadias. Little is known regarding these outcomes in adult patients; our aim is to determine where improvements are needed for long-term management.
The study population comprised adult (>18 years) patients. Demographic data were gathered and patients were asked to fill out 4 validated questionnaires: (1) International Consultation on Incontinence Questionnaire urinary incontinence form (ICIQ-UI) regarding continence; (2) International Prostate Symptom Score (IPSS) for men and International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) for women regarding lower urinary tract symptoms; (3) 12-Item Short Form Health Survey regarding quality of life; (4) International Index of Erectile Function for men and Female Sexual Function Index for women regarding sexual function.
Seventeen patients were included (9 men and 8 women) with a median age of 36 years (range 19-73). Median score on ICIQ-UI was 5/21. Median IPSS score was 7/35 and median quality of life score was 1 (=pleased). Median scores per domain within ICIQ-FLUTS were 7 for storage, 0 for voiding, and 6 for urinary incontinence with bother scores of 4, 0, and 2.8, respectively. Scores for 12-Item Short Form Health Survey in the study population were comparable with those of the Dutch population, except for Physical Component Summary in women. For sexual function, no difference was found between those in the general population and our participants except for the domain "pain" in Female Sexual Function Index.
Adult patients with exstrophy or epispadias have a high rate of incontinence and lower urinary tract symptoms with relatively low to some degree of bother. When compared with the general population, quality of life, and sexual function of our patients were more or less similar.
评估膀胱外翻或尿道上裂患者的泌尿系统功能、性功能和生活质量。对于成年患者的这些结果知之甚少；我们的目的是确定需要在长期管理中改进的地方。
研究人群包括成年（>18 岁）患者。收集人口统计学数据，患者填写了 4 份经过验证的问卷：（1）国际尿失禁咨询问卷尿失禁表（ICIQ-UI）评估尿失禁；（2）男性国际前列腺症状评分（IPSS）和女性国际尿失禁咨询问卷-下尿路症状（ICIQ-FLUTS）评估下尿路症状；（3）12 项简短健康调查评估生活质量；（4）男性国际勃起功能指数和女性性功能指数评估性功能。
共纳入 17 例患者（9 例男性和 8 例女性），中位年龄为 36 岁（范围 19-73 岁）。ICIQ-UI 中位评分为 5/21。IPSS 评分中位值为 7/35，生活质量评分中位值为 1（=满意）。ICIQ-FLUTS 各域评分中位数分别为储存域 7、排尿域 0 和尿失禁域 6，困扰评分分别为 4、0 和 2.8。研究人群中的 12 项简短健康调查评分与荷兰人群相似，除女性的生理成分综合评分外。在性功能方面，除女性性功能指数的“疼痛”域外，我们的参与者与普通人群之间没有差异。
膀胱外翻或尿道上裂的成年患者有较高的失禁率和下尿路症状，且困扰程度相对较低或有些程度的困扰。与普通人群相比，我们患者的生活质量和性功能或多或少相似。
