主基因杂合性对数量性状变异的可能影响。

Possible influence of major gene heterozygosity on variation of quantitative traits.

作者信息

Bishop G R, Mayo O, Beckman L

机构信息

Biometry Section, Waite Agricultural Research Institute, University of Adelaide, Australia.

出版信息

Hum Hered. 1988;38(4):216-27. doi: 10.1159/000153788.

DOI:10.1159/000153788

PMID:3169796

Abstract

The possible explanations for heterosis and heterozygous advantage have included the hypothesis that the metabolic versatility of heterozygotes for functional alleles of structural genes would enhance resistance to environmental insult, i.e. would result in enhanced developmental homeostasis. Evidence on this hypothesis is conflicting. The paper presents additional evidence, based on four human polymorphisms and 9 quantitative traits in a sample of mother-offspring data from Sweden. These data do not support the hypothesis of interest. Reasons for the conflicting results are discussed.

摘要

杂种优势和杂合子优势的可能解释包括这样一种假说，即结构基因功能等位基因杂合子的代谢多样性会增强对环境损伤的抵抗力，也就是说会导致发育稳态增强。关于这一假说的证据相互矛盾。本文基于瑞典母婴数据样本中的四种人类多态性和九个数量性状提供了额外的证据。这些数据并不支持该相关假说。文中讨论了结果相互矛盾的原因。