针对半抗原偶联同基因细胞的杀伤性T细胞的体内生成与调控。

In vivo generation and regulation of killer T-cells directed towards hapten-coupled syngeneic cells.

作者信息

Butler L D, Battisto J R

出版信息

Ann N Y Acad Sci. 1979;332:524-30. doi: 10.1111/j.1749-6632.1979.tb47146.x.

DOI:10.1111/j.1749-6632.1979.tb47146.x

Abstract

We have extended our studies which show that hapten-specific killer T-cells can be generated in vivo towards hapten-conjugated, syngeneic spleen cells provided an auxiliary antigenic stimulus is incorporated. M1s antigen served in this auxiliary capacity by stimulating helper T-cells. Natural or experimental tolerance to these antigens abrogated cytotoxicity. Effecting tolerance in host animals towards target hapten also prevented development of the genetically restricted killer T-cells. Thus, cytolytic T-cells can be controlled equally at the levels of helper and pre-killer cells. While adoptive transfer of hapten-specific tolerance by means of spleen cells did not abrogate appearance of hapten-specific killer T-cells, it did prevent hapten-specific DTH. Thus, the mechanism for regulating the latter may differ significantly from that for CML.

摘要

我们扩展了研究，结果表明，如果引入辅助抗原刺激，针对半抗原结合的同基因脾细胞，体内可产生半抗原特异性杀伤性T细胞。M1s抗原通过刺激辅助性T细胞发挥这种辅助作用。对这些抗原的天然或实验性耐受性消除了细胞毒性。使宿主动物对靶半抗原产生耐受性也阻止了基因限制性杀伤性T细胞的发育。因此，细胞溶解性T细胞在辅助细胞和前杀伤细胞水平上均可得到同等控制。虽然通过脾细胞进行半抗原特异性耐受性的过继转移并没有消除半抗原特异性杀伤性T细胞的出现，但它确实阻止了半抗原特异性迟发型超敏反应。因此，调节后者的机制可能与调节慢性粒细胞白血病的机制有显著差异。

相似文献

1

In vivo generation and regulation of killer T-cells directed towards hapten-coupled syngeneic cells.针对半抗原偶联同基因细胞的杀伤性T细胞的体内生成与调控。

Ann N Y Acad Sci. 1979;332:524-30. doi: 10.1111/j.1749-6632.1979.tb47146.x.

2

In vivo generation of hapten-specific killer T cells without elimination of suppressor cells.在不清除抑制细胞的情况下体内产生半抗原特异性杀伤性T细胞。

J Immunol. 1979 Apr;122(4):1578-81.

3

Use of immunotolerance to dissect the mechanisms regulating appearance of hapten-specific killer T cells in vivo.

J Immunol. 1980 Mar;124(3):1245-50.

4

In vivo regulation of the primary response of cytolytic T cells to hapten-altered self antigens by an inducible suppressor T cell.可诱导性抑制性T细胞对细胞毒性T细胞对半抗原改变的自身抗原的初次反应的体内调节

Ann N Y Acad Sci. 1982;392:144-55. doi: 10.1111/j.1749-6632.1982.tb36104.x.

5

Ongoing hapten-specific delayed-type hypersensitivity prevents generation of cytolytic T lymphocytes to the same hapten.持续存在的半抗原特异性迟发型超敏反应会阻止针对同一半抗原的细胞毒性T淋巴细胞的产生。

Cell Immunol. 1985 Aug;94(1):205-14. doi: 10.1016/0008-8749(85)90097-8.

6

Two distinct suppressor T cells acting in concert cause suppression of cytolytic T lymphocyte (CTL) response to hapten-altered self in vivo.两种不同的抑制性T细胞协同作用，在体内对针对半抗原改变的自身抗原的细胞毒性T淋巴细胞（CTL）反应产生抑制作用。

J Immunol. 1983 Jun;130(6):2557-60.

7

In vivo development of cytolytic T lymphocytes (CTL) to hapten-altered self: MIs-disparate cells facilitate the response by neutralizing IL 2 inhibitor.细胞毒性T淋巴细胞（CTL）对半抗原改变的自身抗原的体内发育：主要组织相容性复合体（MIs）不匹配的细胞通过中和白细胞介素2抑制剂促进反应。

J Immunol. 1983 Feb;130(2):533-7.

8

The influence of hapten-conjugated isologous mouse gamma-globulin as a tolerogen on H-2 restricted cytotoxic effector cells.作为一种耐受原的半抗原结合的同种小鼠γ球蛋白对H-2限制性细胞毒性效应细胞的影响。

J Immunol. 1980 Mar;124(3):1506-9.

9

Characterization of two suppressor cells that together prevent in vivo development of cytolytic T cells to hapten-altered self.两种抑制细胞的特性，它们共同阻止细胞毒性T细胞在体内对半抗原改变的自身抗原的发育。

Cell Immunol. 1984 Aug;87(1):23-34. doi: 10.1016/0008-8749(84)90127-8.

10

Non-H-2-associated genetic regulation of cytotoxic responses to hapten-modified syngeneic cells. Effect on the magnitude of secondary response and helper T cell generation after in vivo priming.对半抗原修饰的同基因细胞细胞毒性反应的非H-2相关遗传调控。对体内致敏后二次反应强度及辅助性T细胞生成的影响。

Eur J Immunol. 1981 Sep;11(9):700-4. doi: 10.1002/eji.1830110906.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。