Mescolini Giulia, Lupini Caterina, Davidson Irit, Massi Paola, Tosi Giovanni, Fiorentini Laura, Catelli Elena
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, BO, Italy.
Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, Israel.
Avian Pathol. 2020 Apr;49(2):202-207. doi: 10.1080/03079457.2019.1691715. Epub 2019 Nov 22.
Marek's disease (MD) is a lymphoproliferative disease caused by (GaHV-2), which primarily affects chickens. However, the virus is also able to induce tumours in turkeys, albeit less frequently than in chickens. This study reports the molecular characterization of a GaHV-2 strain detected in a flock of Italian meat-type turkeys exhibiting visceral lymphomas. Sequencing and phylogenetic analysis of the gene revealed that the turkey GaHV-2 has molecular features of high virulence and genetic similarity with GaHV-2 strains recently detected in Italian commercial and backyard chickens. GaHV-2 is ubiquitous among chickens despite vaccination, and chicken-to-turkey transmission is hypothesized due to the presence of broilers in neighbouring pens. A GaHV-2 strain from Italian turkeys was molecularly characterized.The turkey strain presented molecular characteristics of high virulence in its gene.The turkey strain was closely related to previously detected chicken strains.
马立克氏病（MD）是一种由马立克氏病病毒2型（GaHV - 2）引起的淋巴增生性疾病，主要影响鸡。然而，该病毒也能够在火鸡中诱发肿瘤，尽管其频率低于鸡。本研究报告了在一群表现出内脏淋巴瘤的意大利肉用火鸡中检测到的一株GaHV - 2的分子特征。该病毒基因的测序和系统发育分析表明，火鸡GaHV - 2具有高毒力的分子特征，并且与最近在意大利商业鸡群和后院鸡群中检测到的GaHV - 2毒株具有遗传相似性。尽管进行了疫苗接种，但GaHV - 2在鸡群中普遍存在，由于相邻鸡舍中有肉鸡存在，推测存在从鸡到火鸡的传播。对来自意大利火鸡的一株GaHV - 2进行了分子特征分析。该火鸡毒株在其基因中呈现出高毒力的分子特征。该火鸡毒株与先前检测到的鸡毒株密切相关。
