Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany.
German Center for Neurodegenerative Disease (DZNE), Bonn, Germany.
FASEB J. 2019 Dec;33(12):13075-13084. doi: 10.1096/fj.201900439. Epub 2019 Nov 8.
Historically neurodegenerative diseases, Alzheimer's disease (AD) in particular, have been viewed to be primarily caused and driven by neuronal mechanisms. Very recently, due to experimental, genetic, and epidemiologic evidence, immune mechanisms have entered the central stage and are now believed to contribute significantly to risk, onset, and disease progression of this class of disorders. Although immune activation of microglial cells may over time engage various signal transduction pathways, inflammasome activation, which represents a canonical and initiating pathway, seems to be one of the first responses to extracellular β-amyloid (Aβ) accumulation. Here we review the current understanding of inflammasome activation in AD.-Venegas, C., Heneka, M. T. Inflammasome-mediated innate immunity in Alzheimer's disease.
从历史上看，神经退行性疾病，特别是阿尔茨海默病（AD），被认为主要是由神经元机制引起和驱动的。最近，由于实验、遗传和流行病学证据，免疫机制已经进入了中心舞台，现在被认为对这类疾病的风险、发病和疾病进展有重要贡献。尽管小胶质细胞的免疫激活可能随着时间的推移而涉及各种信号转导途径，但炎症小体的激活，代表了一种典型的起始途径，似乎是对细胞外β-淀粉样蛋白（Aβ）积累的最早反应之一。在这里，我们综述了目前对 AD 中炎症小体激活的理解。-Venegas，C.，Heneka，M. T. 阿尔茨海默病中的炎症小体介导的先天免疫。
