青少年类风湿关节炎同胞关系中的人类白细胞抗原与性别比例改变

HLA and altered sex ratios in juvenile rheumatoid arthritis sibships.

作者信息

Van Kerckhove C, Balakrishnan K, Levinson J E, Larson M G, Glass D N

机构信息

Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.

出版信息

Hum Immunol. 1988 Aug;22(4):227-33. doi: 10.1016/0198-8859(88)90002-x.

DOI:10.1016/0198-8859(88)90002-x

PMID:3170286

Abstract

Analysis of sex ratio in 301 siblings of 150 patients with early-onset pauciarticular juvenile rheumatoid arthritis revealed a male-to-female ratio of 1:2.00 in sibships with an HLA-B44+ proband, compared with a ratio of 1:1.05 in other sibships (G2 = 6.07, df = 1, p = 0.014). The siblings had a sex ratio of 1:0.8, when the HLA-B44 antigen was present in either parent but not transmitted to the proband. The capacity to distort the sex ratio was limited therefore to disease-associated HLA-B44 haplotypes.

摘要

对150例早发型少关节型幼年类风湿关节炎患者的301名同胞的性别比例分析显示，在先证者为HLA - B44阳性的同胞组中，男女比例为1:2.00，而在其他同胞组中这一比例为1:1.05（卡方值=6.07，自由度=1，p=0.014）。当HLA - B44抗原在父母一方中存在但未遗传给先证者时，同胞的性别比例为1:0.8。因此，扭曲性别比例的能力仅限于与疾病相关的HLA - B44单倍型。