HLA相关风湿性疾病中的性别比例与激素
Sex ratios and hormones in HLA related rheumatic diseases.
作者信息
James W H
机构信息
MRC Mammalian Development Unit, University College, London.
出版信息
Ann Rheum Dis. 1991 Jun;50(6):401-4. doi: 10.1136/ard.50.6.401.
The major diseases associated with HLA-B27 (Reiter's disease, ankylosing spondylitis, acute anterior uveitis, and psoriatic arthritis) all occur much more commonly in men. Published evidence indicates that the antigen HLA-B27 is associated with high testosterone concentrations in men. Moreover, the antigen HLA-B44 exerts a protective effect on one of these diseases (psoriatic arthritis), and there are external grounds for supposing that HLA-B44 indexes an antiandrogenic process. These data are interpreted as support for the hypothesis (first adumbrated nearly 20 years ago) that HLA antigens index unusual hormone concentrations, which in turn are causally related to the diseases. An examination of published reports suggests that sibs of probands with ankylosing spondylitis (and perhaps Reiter's disease) contain an excess of men, and that sibs of probands with rheumatoid arthritis contain an excess of women. These data lend further support to the hypothesis.
与HLA - B27相关的主要疾病（赖特综合征、强直性脊柱炎、急性前葡萄膜炎和银屑病关节炎）在男性中更为常见。已发表的证据表明，抗原HLA - B27与男性体内高睾酮浓度相关。此外，抗原HLA - B44对其中一种疾病（银屑病关节炎）具有保护作用，并且有外在理由推测HLA - B44指示了一个抗雄激素过程。这些数据被解释为支持如下假说（近20年前首次提出）：HLA抗原指示异常的激素浓度，而这些激素浓度反过来与疾病存在因果关系。对已发表报告的审查表明，强直性脊柱炎（可能还有赖特综合征）先证者的同胞中男性过多，而类风湿性关节炎先证者的同胞中女性过多。这些数据进一步支持了该假说。
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