Gasparini Mark E, Chang Toby W, St Lezin Mark, Skerry John E, Chan Andy, Ramaswamy Krishna A
South San Francisco Medical Center, CA.
Oakland Medical Center, CA.
Perm J. 2019;23. doi: 10.7812/TPP/19.023. Epub 2019 Nov 1.
Despite guidelines for prevention of recurrent renal calculi, routine dietary modification and metabolic evaluation are often not performed.
To determine feasibility of a multicenter, pharmacist-staffed program to enroll patients at high risk of recurrent kidney stones and provide dietary instruction, metabolic evaluation, and medical therapy via telemedicine.
A total of 536 consecutive adult patients were referred from 3 Northern California Kaiser Permanente facilities. We determined the proportion of patients who enrolled, received dietary counseling, and completed metabolic evaluation at 12 months. The program was staffed by a clinical pharmacist and supervised by urologists following a protocol based on the American Urological Association guidelines. Patients were contacted entirely via telemedicine. Cystine or struvite kidney stones, renal tubular acidosis, and primary hyperoxaluria were exclusion criteria.
Of the 536 patients, 500 agreed to enrollment. Among patients enrolled for 3 months, 99% self-reported compliance with at least 3 of 5 aspects of dietary advice. A complete metabolic evaluation including 24-hour urine collection was performed in 80% of patients by 12 months. A significant improvement in all urinary parameters occurred in 52 patients with calcium stones who repeated 24-hour urine testing. The 12-month dropout rate was 12.4%.
A telemedicine-administered, pharmacist-staffed, protocol-driven program can provide dietary advice and obtain compliance with metabolic testing for patients at high risk of recurrent kidney stones. Rates of metabolic testing and dropout compare favorably with previously reported rates. This report represents, to our knowledge, the first telemedicine-administered, pharmacist-staffed, kidney stone prevention program published in the literature.
尽管有预防复发性肾结石的指南,但常规的饮食调整和代谢评估往往并未实施。
确定一项由药剂师参与的多中心项目的可行性,该项目旨在招募复发性肾结石高危患者,并通过远程医疗提供饮食指导、代谢评估和药物治疗。
从北加利福尼亚州的3家凯撒医疗机构连续转诊了536例成年患者。我们确定了在12个月时登记入组、接受饮食咨询并完成代谢评估的患者比例。该项目由一名临床药剂师负责,并由泌尿科医生按照基于美国泌尿外科学会指南的方案进行监督。患者完全通过远程医疗进行联系。胱氨酸或鸟粪石性肾结石、肾小管酸中毒和原发性高草酸尿症为排除标准。
536例患者中,500例同意入组。在入组3个月的患者中,99%的患者自我报告至少遵守了饮食建议5个方面中的3个方面。到12个月时,80%的患者进行了包括24小时尿液收集在内的完整代谢评估。52例复发性钙结石患者重复进行24小时尿液检测后,所有尿液参数均有显著改善。12个月时的退出率为12.4%。
一个由远程医疗管理、药剂师参与、方案驱动的项目可以为复发性肾结石高危患者提供饮食建议,并使患者配合代谢检测。代谢检测率和退出率与先前报道的比率相比更有利。据我们所知,本报告是文献中发表的首个由远程医疗管理、药剂师参与的肾结石预防项目。