Pishgahi Alireza, Dolatkhah Neda, Shakouri Seyed Kazem, Hashemian Maryam, Amiri Atefeh, Delkhosh Reihany Morteza, Jahanjou Fatemeh
Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Emam Reza Hospital, Golgasht, Azadi Ave., Tabriz, Iran.
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
BMC Res Notes. 2019 Nov 8;12(1):738. doi: 10.1186/s13104-019-4768-0.
Low back pain (LBP) is a common medical problem worldwide. The aim of this study is to evaluate the association between serum concentration of 25-hydroxivitamin D3 and functional disability in patients suffering from LBP in a sample of Azeri middle-aged subjects, North West of Iran.
In this case-control study, 63 eligible patients with LBP and 55 healthy subjects enrolled in the study. Peripheral venous blood was taken for evaluating the serum concentration of 25-hydroxivitamin D3. We recognized factors related with LBP by multiple regression analyses. The average serum 25-hydroxivitamin D3 concentration in case group was significantly lower than that of the matched controlled group (26.25 ± 15.95 vs. 34.20 ± 14.92, p-value < 0.01 respectively). Subjects with vitamin D deficiency or insufficiency were more likely to exhibit LBP than subjects with normal serum 25-hydroxivitamin D3 concentration [(OR = 2.388, 95% CI (1.114 to 5.119)]. According to the partial correlation analysis, there was a reverse correlation between serum 25-hydroxivitamin D3 concentration with functional disability measured by Modified Oswestry Questionnaire (r = - 0.307, p = 0.017) and also with pain intensity according to Visual Analogue Scale (VAS) score (r = - 0.268, p = 0.040) whilst adjusting for age, sex and body mass index (BMI).
腰痛（LBP）是全球常见的医学问题。本研究旨在评估伊朗西北部阿塞拜疆中年受试者样本中，患有腰痛的患者血清25-羟基维生素D3浓度与功能障碍之间的关联。
在这项病例对照研究中，63例符合条件的腰痛患者和55名健康受试者参与了研究。采集外周静脉血以评估血清25-羟基维生素D3浓度。我们通过多元回归分析识别与腰痛相关的因素。病例组血清25-羟基维生素D3的平均浓度显著低于匹配的对照组（分别为26.25±15.95和34.20±14.92，p值<0.01）。维生素D缺乏或不足的受试者比血清25-羟基维生素D3浓度正常的受试者更易出现腰痛[（比值比=2.388，95%置信区间（1.114至5.119）]。根据偏相关分析，在调整年龄、性别和体重指数（BMI）后，血清25-羟基维生素D3浓度与改良Oswestry问卷测量的功能障碍之间呈负相关（r=-0.307，p=0.017），与视觉模拟量表（VAS）评分的疼痛强度也呈负相关（r=-0.268，p=0.040）。
