Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
MedFuture Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Mol Aspects Med. 2019 Dec;70:90-105. doi: 10.1016/j.mam.2019.10.007. Epub 2019 Nov 6.
MicroRNAs (miRNAs) are non-coding transcripts which regulate genetic and epigenetic events by interfering with mRNA translation. miRNAs are involved in regulation of cell fate due to their ability of interfering with physiological or pathological processes. In this review paper, we evaluate the role of miR-181 family members as prognostic or diagnostic markers or therapeutic targets in malignant pathologies in connection with the main hallmarks of cancer that are modulated by the family. Also, we take over the dual role of this family in dependency with the tumour suppressor and oncogenic features presented in cell and cancer type specific manner. Restoration of the altered expression levels contributes to the activation of cell death pathways or to a reduction in the invasion and migration mechanism; moreover, the mechanism of drug resistance is also modulated by miR-181 sequences with important applications in therapeutic strategies for malignant cells sensitisation. Overall, the main miR-181 family regulatory mechanisms are presented in a cancer specific context, emphasizing the possible clinical application of this family in terms of novel diagnosis and therapy approaches.
MicroRNAs (miRNAs) 是一类非编码转录物，通过干扰 mRNA 翻译来调节遗传和表观遗传事件。miRNAs 能够干扰生理或病理过程，因此参与调节细胞命运。在这篇综述中，我们评估了 miR-181 家族成员作为与家族调节的癌症主要特征相关的恶性病理中的预后或诊断标志物或治疗靶点的作用。此外，我们还考虑了该家族在细胞和癌症类型特异性方式下呈现的肿瘤抑制和致癌特征的双重作用。改变表达水平的恢复有助于激活细胞死亡途径或减少侵袭和迁移机制；此外，miR-181 序列还调节耐药机制，在恶性细胞增敏的治疗策略中有重要应用。总的来说，主要的 miR-181 家族调控机制在癌症特定背景下呈现出来，强调了该家族在新型诊断和治疗方法方面的可能临床应用。
