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Gastrointestinal manifestations in common variable immunodeficiency (CVID) are associated with an altered immunophenotype including B- and T-cell dysregulation.普通可变免疫缺陷（CVID）中的胃肠道表现与免疫表型改变有关，包括B细胞和T细胞调节异常。
J Allergy Clin Immunol Pract. 2020 Apr;8(4):1436-1438.e1. doi: 10.1016/j.jaip.2019.10.024. Epub 2019 Nov 5.
2
Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21 B cells.患有自身免疫性疾病的常见可变免疫缺陷（CVID）患者中调节性T细胞比例较低及其与CD4 + CD45RO + T细胞和CD21 B细胞数量增加的关联。
Allergol Immunopathol (Madr). 2019 Sep-Oct;47(5):457-466. doi: 10.1016/j.aller.2019.01.003. Epub 2019 May 15.
3
Modulation of the Interleukin-21 Pathway with Interleukin-4 Distinguishes Common Variable Immunodeficiency Patients with More Non-infectious Clinical Complications.白细胞介素-4 对白细胞介素-21 通路的调节可区分具有更多非传染性临床并发症的普通可变免疫缺陷患者。
J Clin Immunol. 2018 Jan;38(1):45-55. doi: 10.1007/s10875-017-0452-0. Epub 2017 Nov 4.
4
Common variable immunodeficiency and the gastrointestinal tract.普通可变免疫缺陷与胃肠道
Curr Gastroenterol Rep. 2004 Oct;6(5):377-83. doi: 10.1007/s11894-004-0053-y.
5
A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.常见可变免疫缺陷中胃肠道表现的高患病率。
Am J Gastroenterol. 2019 Apr;114(4):648-655. doi: 10.14309/ajg.0000000000000140.
6
Common variable immunodeficiency at the end of a prospering decade: towards novel gene defects and beyond.在繁荣的十年结束时的常见可变免疫缺陷：走向新的基因缺陷和超越。
Curr Opin Allergy Clin Immunol. 2010 Dec;10(6):526-33. doi: 10.1097/ACI.0b013e32833fea1c.
7
Autoimmunity in common variable immunodeficiency: correlation with lymphocyte phenotype in the French DEFI study.常见可变免疫缺陷中的自身免疫：与法国 DEFI 研究中的淋巴细胞表型的相关性。
J Autoimmun. 2011 Feb;36(1):25-32. doi: 10.1016/j.jaut.2010.10.002. Epub 2010 Nov 13.
8
Current Understanding and Recent Developments in Common Variable Immunodeficiency Associated Autoimmunity.常见可变免疫缺陷相关自身免疫的当前认识和最新进展。
Front Immunol. 2019 Dec 10;10:2753. doi: 10.3389/fimmu.2019.02753. eCollection 2019.
9
Differentiation of Common Variable Immunodeficiency From IgG Deficiency.普通变异性免疫缺陷与 IgG 缺乏症的鉴别。
J Allergy Clin Immunol Pract. 2019 Apr;7(4):1277-1284. doi: 10.1016/j.jaip.2018.12.004. Epub 2018 Dec 14.
10
Flowcytometric phenotyping of common variable immunodeficiency.常见可变免疫缺陷的流式细胞术表型分析
Cytometry B Clin Cytom. 2008 Sep;74(5):261-71. doi: 10.1002/cyto.b.20432.

引用本文的文献

1
Characterization of infectious and non-infectious gastrointestinal disease in common variable immunodeficiency: analysis of 114 patient cohort.常见可变免疫缺陷症中感染性和非感染性胃肠道疾病的特征：114 例患者队列分析。
Front Immunol. 2023 Aug 30;14:1209570. doi: 10.3389/fimmu.2023.1209570. eCollection 2023.
2
Clinical manifestations and approach to the management of patients with common variable immunodeficiency and liver disease.常见可变免疫缺陷和肝病患者的临床表现及处理方法。
Front Immunol. 2023 Jun 5;14:1197361. doi: 10.3389/fimmu.2023.1197361. eCollection 2023.
3
Predominant Antibody Deficiency and Risk of Microscopic Colitis: a Nationwide Case-Control Study in Sweden.优势抗体缺乏与显微镜下结肠炎风险：瑞典全国病例对照研究。
J Clin Immunol. 2023 Aug;43(6):1426-1435. doi: 10.1007/s10875-023-01499-3. Epub 2023 May 10.

本文引用的文献

1
A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.常见可变免疫缺陷中胃肠道表现的高患病率。
Am J Gastroenterol. 2019 Apr;114(4):648-655. doi: 10.14309/ajg.0000000000000140.
2
Common Variable Immunodeficiency Non-Infectious Disease Endotypes Redefined Using Unbiased Network Clustering in Large Electronic Datasets.利用大型电子数据集中的无偏网络聚类重新定义常见可变免疫缺陷非感染性疾病内型。
Front Immunol. 2018 Jan 9;8:1740. doi: 10.3389/fimmu.2017.01740. eCollection 2017.
3
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency.普通可变免疫缺陷患者胃肠道症状和病理患病率的横断面研究
Am J Gastroenterol. 2016 Oct;111(10):1467-1475. doi: 10.1038/ajg.2016.329. Epub 2016 Aug 16.
4
Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency.常见变异型免疫缺陷中TCR库多样性的加速丧失
J Immunol. 2016 Sep 1;197(5):1642-9. doi: 10.4049/jimmunol.1600526. Epub 2016 Aug 1.
5
Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD).与常见可变免疫缺陷（CVID）和慢性肉芽肿病（CGD）相关的胃肠道疾病
Curr Gastroenterol Rep. 2016 Apr;18(4):17. doi: 10.1007/s11894-016-0491-3.
6
International Consensus Document (ICON): Common Variable Immunodeficiency Disorders.国际共识文件（ICON）：常见变异型免疫缺陷病
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. doi: 10.1016/j.jaip.2015.07.025. Epub 2015 Nov 7.
7
Clonal and constricted T cell repertoire in Common Variable Immune Deficiency.常见变异型免疫缺陷中克隆性和受限的T细胞受体库
Clin Immunol. 2017 May;178:1-9. doi: 10.1016/j.clim.2015.01.002. Epub 2015 Jan 14.
8
Morbidity and mortality in common variable immune deficiency over 4 decades.四十余年来常见可变免疫缺陷的发病率和死亡率。
Blood. 2012 Feb 16;119(7):1650-7. doi: 10.1182/blood-2011-09-377945. Epub 2011 Dec 16.
9
Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review.普通可变免疫缺陷（CVID）患者的胃肠道病理学：一项临床病理研究与综述
Am J Surg Pathol. 2007 Dec;31(12):1800-12. doi: 10.1097/PAS.0b013e3180cab60c.

Gastrointestinal manifestations in common variable immunodeficiency (CVID) are associated with an altered immunophenotype including B- and T-cell dysregulation.

作者信息

Barmettler Sara, Ong Mei-Sing, Farmer Jocelyn R, Yang Nancy, Cobbold Mark, Walter Jolan E, Long Aidan A, Camargo Carlos A

机构信息

Massachusetts General Hospital, Boston, Mass.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass.

出版信息

J Allergy Clin Immunol Pract. 2020 Apr;8(4):1436-1438.e1. doi: 10.1016/j.jaip.2019.10.024. Epub 2019 Nov 5.

DOI:10.1016/j.jaip.2019.10.024
PMID:31704440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7438162/
Abstract
摘要